In progress - Scheduled maintenance is currently in progress. We will provide updates as necessary.
May 01, 2024 - 13:00 BST
May 01, 2024 - 13:00 BST
Scheduled - Dear all,
We would like to inform you of planned software releases for the NGIS production environment.
Mira - (NGIS version 1.48.7) and Cancer DSSv6.0.0 will be released on Wednesday, 01 May 2024 from 13:00 (BST) to 21:00 (BST).
The Mira and Cancer DSS Release notes are available in the Forward Schedule of Change portal.
The main changes in these releases are:
- Dragen v4 for RD - Tumour First / Germline Late
- PanelApp Data changes - GRM Update
- VIL Improvements
- Prioritise variants in known disease associated non-coding genes (non-MT)
- Removal of BSVI access from the Interpretation Portal
- Some accessibility changes, bug fixes for Cancer DSS and a move of the DSS to a new infrastructure
Please note that all NGIS applications except for Test Ordering will be unavailable in the NGIS production environment during the advised timeframe.
May 1, 2024 13:00-21:00 BST
We would like to inform you of planned software releases for the NGIS production environment.
Mira - (NGIS version 1.48.7) and Cancer DSSv6.0.0 will be released on Wednesday, 01 May 2024 from 13:00 (BST) to 21:00 (BST).
The Mira and Cancer DSS Release notes are available in the Forward Schedule of Change portal.
The main changes in these releases are:
- Dragen v4 for RD - Tumour First / Germline Late
- PanelApp Data changes - GRM Update
- VIL Improvements
- Prioritise variants in known disease associated non-coding genes (non-MT)
- Removal of BSVI access from the Interpretation Portal
- Some accessibility changes, bug fixes for Cancer DSS and a move of the DSS to a new infrastructure
Please note that all NGIS applications except for Test Ordering will be unavailable in the NGIS production environment during the advised timeframe.
May 1, 2024 13:00-21:00 BST
Update - SERVICE:
NGIS Tumor Samples
SEVERITY:
2
GEL REF:
GEL-206086
DESCRIPTION:
Tumor samples failing a non-contractual T>G metric
SUMMARY OF IMPACT:
This is a reminder that this incident is still being investigated by Ilumina and please be vigilant when analysing cases
.
We have been notified by Illumina that a subset of tumour samples have been failing a non-contractual T>G metric and the issue is currently being investigated by Illumina. We have confirmation from Illumina that the issue is not connected to the T>G issue we experienced last year. Any samples with the failed metric have been re-sequenced.
There are 9 cases where T>G fraction is still exceeding cut-off after re-sequencing. We have contacted affected GLHs with a list of samples with any next steps options. Upon inspecting sequencing data in IGV we believe a larger number of cases can be impacted to a lesser degree. We recommend reviewing any reportable variants in IGV to exclude clinical reporting of false positive variants.
Oct 02, 2023 - 09:47 BST
NGIS Tumor Samples
SEVERITY:
2
GEL REF:
GEL-206086
DESCRIPTION:
Tumor samples failing a non-contractual T>G metric
SUMMARY OF IMPACT:
This is a reminder that this incident is still being investigated by Ilumina and please be vigilant when analysing cases
.
We have been notified by Illumina that a subset of tumour samples have been failing a non-contractual T>G metric and the issue is currently being investigated by Illumina. We have confirmation from Illumina that the issue is not connected to the T>G issue we experienced last year. Any samples with the failed metric have been re-sequenced.
There are 9 cases where T>G fraction is still exceeding cut-off after re-sequencing. We have contacted affected GLHs with a list of samples with any next steps options. Upon inspecting sequencing data in IGV we believe a larger number of cases can be impacted to a lesser degree. We recommend reviewing any reportable variants in IGV to exclude clinical reporting of false positive variants.
Oct 02, 2023 - 09:47 BST
Investigating - SERVICE:
NGIS Tumor Samples
SEVERITY:
2
GEL REF:
GEL-206086
DESCRIPTION:
Tumor samples failing a non-contractual T>G metric
SUMMARY OF IMPACT:
We have been notified by Illumina that a subset of tumour samples have been failing a non-contractual T>G metric and the issue is currently being investigated by Illumina. We have confirmation from Illumina that the issue is not connected to the T>G issue we experienced last year.
Any samples with the failed metric have been re-sequenced. There are 8 cases where T>G fraction is still exceeding cut-off after re-sequencing. We have contacted affected GLHs with a list of samples with any next steps options.
Upon inspecting sequencing data in IGV we believe a larger number of cases can be impacted to a lesser degree. We recommend reviewing any reportable variants in IGV to exclude clinical reporting of false positive variants.
Sep 19, 2023 - 09:33 BST
NGIS Tumor Samples
SEVERITY:
2
GEL REF:
GEL-206086
DESCRIPTION:
Tumor samples failing a non-contractual T>G metric
SUMMARY OF IMPACT:
We have been notified by Illumina that a subset of tumour samples have been failing a non-contractual T>G metric and the issue is currently being investigated by Illumina. We have confirmation from Illumina that the issue is not connected to the T>G issue we experienced last year.
Any samples with the failed metric have been re-sequenced. There are 8 cases where T>G fraction is still exceeding cut-off after re-sequencing. We have contacted affected GLHs with a list of samples with any next steps options.
Upon inspecting sequencing data in IGV we believe a larger number of cases can be impacted to a lesser degree. We recommend reviewing any reportable variants in IGV to exclude clinical reporting of false positive variants.
Sep 19, 2023 - 09:33 BST
Identified - The issue has been identified and the fix needs to be implemented.
Aug 04, 2023 - 11:38 BST
Aug 04, 2023 - 11:38 BST
Investigating - Dear Researcher,
We are aware that Ensembl is currently not available due to network problems.
Our teams are working on the issue as a matter of urgency and will update you as soon as we have more information.
We apologise for any inconvenience caused.
Best wishes,
Genomics England
Jun 30, 2023 - 18:03 BST
We are aware that Ensembl is currently not available due to network problems.
Our teams are working on the issue as a matter of urgency and will update you as soon as we have more information.
We apologise for any inconvenience caused.
Best wishes,
Genomics England
Jun 30, 2023 - 18:03 BST
General_Service_Updates_Genomics_England
Operational
NGIS_Production_Environment
Under Maintenance
General_Service_Updates_NGIS_Production
?
Under Maintenance
NGIS_PROD_Test_Selection
Operational
NGIS_PROD_Test_Ordering
Operational
NGIS_PROD_SFTP
Under Maintenance
NGIS_PROD_M.I.Portal
Under Maintenance
NGIS_PROD_Sample_Matching_Service
Under Maintenance
NGIS_PROD_Interpretation_Portal
Under Maintenance
NGIS_PROD_CIP-API
Under Maintenance
NGIS_PROD_CVA
Under Maintenance
NGIS_PROD_IGV
Under Maintenance
NGIS_PROD_SNP
Under Maintenance
NGIS_PROD_BSVI
Under Maintenance
NGIS_PROD_Congenica
Under Maintenance
NGIS_PROD_Cancer_Bridge_DSS
Under Maintenance
NGIS_UAT_Environment
Operational
General_Service_Updates_NGIS_UAT
?
Operational
NGIS_UAT_Test_Selection
Operational
NGIS_UAT_Test_Ordering
Operational
NGIS_UAT_SFTP
Operational
NGIS_UAT_M.I.Portal
Operational
NGIS_UAT_Sample_Matching_Service
Operational
NGIS_UAT_Congenica
Operational
NGIS_UAT_Interpretation_Portal
Operational
NGIS_UAT_Bertha
Operational
NGIS_UAT_CIP_API
Operational
NGIS_UAT_SNP
Operational
NGIS_UAT_BSVI
Operational
NGIS_UAT_Cancer_Bridge_DSS
Operational
Third Party Integrator
Operational
Third Party Integrator - Production
Operational
Third Party Integrator - UAT
Operational
Third Party Integrator - SIT
Operational
100K_Applications
Operational
100K_Interpretation_Portal
Operational
100K_CIP-API
Operational
100K_SNP
Operational
100K_Congenica
Operational
100K_MI_Portal
Operational
General_Service_Updates_100K_Applications
Operational
Cloud_RE
Operational
General_Service_Updates_Cloud_RE
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Operational
CloudOS
Operational
VDI
Operational
AWS_Workspace
Operational
Research_Environment
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General_Service_Updates_Research_Environment
Operational
RE_Inuvika
?
Operational
RE_Confluence
?
Operational
RE_Labkey
Operational
RE_Data_Discovery_Portal
Operational
RE_High_Performance_Compute_HPC_HELIX
Operational
RE_Participant_Explorer
Operational
RE_Research_Portal
Operational
RE_IVA
Operational
RE_Airlock_MFT
Operational
Atlassian_Suite
Operational
GE_Jira_Service_Desk
Operational
GE_Jira
Operational
GE_Confluence
Operational
PanelApp
Under Maintenance
Generation Study (Newborns)
Operational
Generation Study Portal
Operational
Generation Study Website
Operational
Generation Study CRM
Operational
Variant Review Tool
Operational
Tableau
Operational
Tableau_Production_Internal
Operational
Tableau_Production_External (Coming Soon)
?
Operational
Aspera
Operational
Aspera
?
Operational
GitLab
Operational
GitLab
Operational
Artifactory
Operational
Artifactory
?
Operational
WEKA Storage Platform
Operational
WEKA
?
Operational
Lumen
Operational
Lumen Internet Connectivity
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Operational
Manage Engine
Operational
Manage Engine (Self-Service)
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Operational
Manage Engine (AD Manager Plus)
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Operational
Semarchy
Operational
Semarchy Master Data Management
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Operational
Operational
Degraded Performance
Partial Outage
Major Outage
Maintenance
Major outage
Partial outage
No downtime recorded on this day.
No data exists for this day.
had a major outage.
had a partial outage.
Scheduled Maintenance
NGIS Production Environment: Congenica Case Deletion - 02 May 2024
May 2, 2024 09:00-17:00 BST
Dear Congenica User,
This is a reminder that GEL will be deleting cases from Congenica on a regular basis. The cases that will be marked for deletion will be the ones that have been closed for 2 weeks in the Interpretation Portal, this is regardless of the amount of time that it has been in Congenica. Closed is defined as the report/summary of findings and exit questionnaire being completed by the user.
The next set of deletions will take place on the Thursday, 02 May 2024.
If you wish to keep a case in Congenica, we advise that you inform the Genomics England Service Desk at least 3 days in advance of the 2 week mark for your case.
Posted on Apr 19, 2024 - 11:23 BST
This is a reminder that GEL will be deleting cases from Congenica on a regular basis. The cases that will be marked for deletion will be the ones that have been closed for 2 weeks in the Interpretation Portal, this is regardless of the amount of time that it has been in Congenica. Closed is defined as the report/summary of findings and exit questionnaire being completed by the user.
The next set of deletions will take place on the Thursday, 02 May 2024.
If you wish to keep a case in Congenica, we advise that you inform the Genomics England Service Desk at least 3 days in advance of the 2 week mark for your case.
Posted on Apr 19, 2024 - 11:23 BST